- Saturday, August 5, 2000
- Extractional - Spectrophotometric Determination
- Published at:Scientia Pharmaceutica (Sci. Pharm.) 68, 109—122 (2000)
ALl Z. ABU ZUHRI*j), WOLFGANG VOELTER2, SULEIMAN AL-KHALIL’,
AND IMAD SALAHAT1
Methods for spectrophotometric determination of fenbendazole and ornidazde are described. The methods are based on the formation and extraction of the ion-pair complex formed between bromothymol blue and either fenbendazole (FBZ) or ornidazole (ORN’). The extracted coloured complexes absorb at 416 and 446 nm, respectively. The effect of different factors, e.g. pH, organic solvent, reagent concentration, extraction time, shaking time and common interfering species have been investigated.
Fenbendazole and ornidazole can be determined over the range 1.2 to 24.0 ppm and 5.5 to 77.0 ppm, respectively. The precision of the methods was tested for the determination of pure samples of FBZ and ORN and the mean RSD was found to be 3.0 and 2.3% for FBZ and ORN, respectively.