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  • Friday, January 30, 2009
  • Hospital outbreak of vancomycin-resistant enterococci caused by a single clone of Enterococcus raffinosus and several clones of Enterococcus faecium
  • Published at:Not Found

    M. Kawalec

    , J. Ke¸dzierska, A. Gajda, E. Sadowy, J. We¸grzyn, S. M. Naser, A. B. Skotnicki ,M. Gniadkowski and W. Hryniewicz

    A mixed outbreak caused by vancomycin-resistant

    Enterococcus raffinosus and Enterococcus faecium

    carrying the

    vanA gene was analysed. The outbreak occurred in a large hospital in Poland and affected

    27 patients, most of whom were colonised, in three wards, including the haematology unit. The

    E. raffinosus

    isolates had a high-level multiresistant phenotype and were initially misidentified as

    Enterococcus avium

    ; their unambiguous identification was provided by multilocus sequence analysis. The

    molecular investigation demonstrated the clonal character of the

    E. raffinosus outbreak and the

    polyclonal structure of the

    E. faecium isolates. All of the isolates carried the same Tn1546-like element

    containing an IS

    1251-like insertion sequence, located on a c. 50-kb conjugative plasmid. One of the

    E. faecium

    clones, found previously to be endemic in the hospital, was probably the source of the

    plasmid. The results of the study suggest that difficulties in identification may have led to an

    underestimate of the importance of

    E. raffinosus in vancomycin-resistant enterococci (VRE) control


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Sabri Mahmoud Sabri Naser
Biotechnology (Molecular Biology and Bioinformatics)
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