Sweileh WM. EFFECT OF COMBINED TREATMENT OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND DIURETICS ON SERUM CREATININE LEVELS AMONG ELDERLY PATIENTS. Saudi Pharmaceutical Journal, 2006; 14(3-4):196-200.


Clinical Pharmacology, College of Pharmacy, An-Najah National University, Nablus, Palestine. E-mail: [email protected]

Abstract:

Background: The adverse effects of angiotensin converting enzyme inhibitors (ACE-I) and diuretics when given together need extensive research and attention. Methods: We performed a cross-sectional study of patients admitted to the internal department of a general medical hospital to investigate the effect of drug combinations on serum creatinine level and creatinine clearance upon admission. Results: age, sex, disease status and prior consumption of the \'target\' drugs: diuretics and ACE-I were correlated with creatinine and creatinine clearance on admission. The levels of serum creatinine for groups receiving the target combination in both sexes were significantly higher than groups who were not receiving the target combination. Computing an estimate of creatinine clearance based on Cockroft equation yields similar results to that for serum level creatinine. The levels of creatinine clearance in both sexes were significantly higher in the control group compared to those receiving the target combinations. Low dose aspirin seems to have a synergistic negative effect on renal function when given in combination with the target medications. Conclusion: taking ACE-I/diuretic combination was associated with significant changes in creatinine levels and creatinine clearance. Attention should be made to balance positive effects of these medications against their negative effect on renal function.

Key words: ACE-I, diuretics, serum creatinine, renal impairment.

Links: http://wwww.ksu.edu.sa/colleges/pharm/SPJ/1434/143408.pdf