As part of the DESIRE project seismic wide-angle reflection / refraction (WRR) and near-vertical incidence reflection (NVR) measurements were completed in spring 2006 across the Dead Sea Transform (DST) in the region of the southern Dead Sea basin. The DST with a total of about 105 km multi-stage left-lateral shear since about 18 Ma ago, accommodates the movement between the Arabian and African plates. It connects the spreading centre in the Red Sea with the Taurus collision zone in Turkey over a length of about 1100 km. With a sedimentary infill of about 10 km in places, the southern Dead Sea basin is the largest pull-apart basin along the DST and one of the largest pull-apart basins on Earth. The WRR measurements comprised 11 shots recorded by 200 three-component and 400 one-component instruments spaced 300 m to 1.2 km apart along the whole length of the E-W trending 240 km long profile. The NVR measurements were carried out along the central 100 km of the E-W trending profile and consisted of a 90-fold vibroseis survey along the western 50 km and an 18-fold explosive source survey along the eastern 50 km of the profile. First results of modelling of the P-wave WRR data and a field example from the NVR data will be presented. Together with results from previously completed seismic profiles in the region, these new results will constrain models of the formation of the Dead Sea Transform (DST) in the region of the southern Dead Sea basin.