- Tuesday, November 25, 2014
- Synthesis of Naproxen pro-drugs for enhanced transdermal absorption
- Published at:Journal of Chemical and Pharmaceutical Research, 2014, 6(8):1-4
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as Naproxen have been used for a long time for the
treatment of acute and chronic inflammation conditions. However, the oral administration of NSAIDs for a long
time can cause gastric mucosal damage, which may result in ulceration and bleeding. Therefore, the development of
a transdermal drug delivery (TDD) system of NSAIDs is of a great interest as it decreases GIT side effect and
provides a constant release of drug in a determined period of time.