An-Najah National University

Curriculum Vita


  • Thursday, January 1, 2009
  • Antibacterial Activity of Common Varthemia, Varthemia iphionoides Ethanol Extract Alone and in Combination with Cefotaxime
  • Published at:Advances in Biological Research 3 (5-6): 144-147, 2009
  • To assess the clinical utility of the crude ethanolic extract of the leaves of Varthemia iphionoides (Compositae), minimal inhibitory concentrations eJ\'v1Ies) were determined using agar dilution technique. Accordingly, The MICs of this plant extract ranged from 0.0313-1 mg/ml for three clinical Staphylacaccus aureus strains and ATCC strains of Bacillus subtilis and Staphylococcus epidermidis, whereas Escherichia coli studied in this report was fOlUld to exhibit higher 1v1Ie value (4 mg/ml). The effect of combinations of ethanolic extract of Varthemia iphionoides and cefotaxime was investigated by means of fractional inhibitory concentration (FIe) indices. Using the FIe indices, synergistic interactions were observed against B. subtilis (ATCC 6633) and S. aureus strains (FIC indices of 0.75-0.875); while combinations against E. cali and S. epidermidis (ATCC 25923) exhibited antagonistic interactions (FIC indices of 2.5 to 16.4). Synergy was confirmed at cefotaxime concentrations corresponding to 1/2 MIC and
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  • Monday, September 1, 2008
  • In vitro activity of certain drugs in combination with plant extracts against Staphylococcus aureus infections
  • Published at:PAKISTAN JOURNAL OF MEDICAL SCIENCES Volume: 24 Issue: 4 Pages: 541-544 Published: JUL-SEP 2008
  • Objectives: This study has been done to evaluate the interaction between ethanolic extracts of Rhus coriaria (seed), Psidium guajava (Leaf), Lawsonia inermis (Leaf) and Sacropoterium spinosum (seed) and antimicrobial drugs including oxytetracycline HCl, enrofloxacin, gentamicin sulphate and sulfadimethoxine against four clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
    Methodology: Evaluation of the interaction between ethanolic extracts and different antimicrobial agents has been done using well-diffusion method.
    Results: It showed that ethanolic extracts increase the inhibition zones of oxytetracycline HCl, gentamicin sulphate, and sulfadimethoxine, while combinations between these plant extracts and enrofloxacin decrease inhibition zone.
    Conclusion: This study probably suggests the possibility of concurrent use of these antimicrobial drugs and plant extracts in combination in treating infections caused by S. aureus strains or at least the concomitant administrati
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  • Sunday, June 1, 2008
  • Enterotoxigenecity of S. Aureus Isolates Recovered from Chronic Urogenital Tract Infection in North Palestine
  • Published at:PAKISTAN JOURNAL OF MEDICAL SCIENCES Volume: 24 Issue: 2 Pages: 246-250 Part: Part 1 Published: APR-JUN 2008
  • Objectives: Staphylococcus aureus is an important pathogen associated with diseases in a variety of hosts including humans. It produces several toxins and virulence factors that contribute to its pathogenic potential such as staphylococcal enterotoxins (SEs). This study was conducted to determine enterotoxigenicity of S. aureus associated with chronic urogenital tract infection by detecting enterotoxin genes.
    Setting: This study was done in The Microbiology laboratory, An-Najah N. University, Palestine.
    Methodology: A total of 90 S. aureus isolates recovered from clinical samples from patients suffering from chronic urogenital tract infection in the North of Palestine were used to detect the presence of staphylococcal enterotoxin genes sea, seb, sec, sed and see by polymerase chain reaction (PCR) assay.
    Results: Out of 90 S. aureus isolates tested, it was found that 57 (63.3%) of these isolates harboured one or more enterotoxin genes. Up to 78.9% of the enterotoxigenic isolates possessed
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  • Tuesday, January 1, 2008
  • Efficacy of Aqueous and Ethanol Extracts of Some Palestinian Medicinal Plants for Potential Antibacterial Activity
  • Published at:The Islamic University Journal (Series of Natural Studies and Engineering), Vol.16, No.2, pp 77-86, 2008
  • Nine medicinal plants growing in Palestine were screened in vitro for potential antibacterial activity against 6 bacterial strains by well diffusion and micro-dilution techniques. Both aqueous and organic solvents were used. The dried extracts of Sacropoterium spinosum (Rosaceae) (seed), Ruta chalepensis L (Rutaceae) (leaf), Cassia senna (Ligumenosa) (leaf), Lawsonia inermis (Lythraceae) (leaf), Psidium guajava (Myrtaceae) (Leaf), Carataegus azerullus (Rosaceae) (Leaf), Ranunclus asiaticus(Ranunculaceae) (Flowers), Calendula officinalis (Composita) (Flowers),and Salvia syriaca (Labiatae) (leaf) were screened. The bacterial strains tested were; Methicillin-resistant Staphylococcus aureus (MRSA); three strains (1, 2 & 3), multidrug resistant Pseudomonas aeruginosa, Proteus vulgaris and Klebsiella pneumonia. The average diameter of inhibition zones ranged from 9 to 30 mm and 11 to 28 mm for aqueous and ethanol extract, respectively. Methicillin-resistant Staphylococcus aureus (MRSA) was the most inhibited mi
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  • Sunday, January 1, 2006
  • Antibacterial Effects of Nutraceutical Plants Growing in Palestine on Pseudomonas aeruginosa
  • Published at:Turk J Biol, 30 (2006) 239-242
  • The antibacterial effects of single and combined plant extracts of water, ethanol and methanol for two nutraceuticals utilized in Palestine were studied against multiple drug resistances Pseudomonas aeruginosa using well diffusion method. These plants are Rhus coriaria and Thymus vulgaris. Combinations of these extracts showed an additive action against this pathogen.
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Kamel Adwan
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