An-Najah Blogs : Jihad Mustafa Abdallah

Monday, March 16, 2009
Linkage disequilibrium fine mapping of quantitative trait loci: a simulation study
Published at:Genet. Sel. Evol. 35 (2003) 513–532
Abstract – Recently, the use of linkage disequilibrium (LD) to locate genes which affect
quantitative traits (QTL) has received an increasing interest, but the plausibility of fine mapping
using linkage disequilibrium techniques for QTL has not been well studied. Themain objectives
of thiswork were to (1)measure the extent and pattern of LD between a putativeQTL and nearby
markers in finite populations and (2) investigate the usefulness of LD in fine mapping QTL in
simulated populations using a dense map of multiallelic or biallelic marker loci. The test of
association between amarker and QTL and the power of the test were calculated based on singlemarker regression analysis. The results show the presence of substantial linkage disequilibrium with closely linked marker loci after 100 to 200 generations of random mating. Although the power to test the association with a frequent QTL of large effect was satisfactory, the power was low for the QTL with a small ef
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Saturday, February 7, 2009
A comparison between methods for linkage disequilibrium fine mapping of quantitative trait loci
Published at:Not Found
We present a maximum liklihood method for mapping quantitative trait loci that uses linkage disequilibrium information from single and multiple markers. We made paired comparisons between analyses using a single marker, two markers and six markers. We also compared the method to single marker regression analysis under several scenarios using simulated data.In general our method outperformed regression (smaller mean square error and confidence intervals of location estimate) for quantitative trait loci with dominance effects. In addition, the method provides estimates of the frequency and additive and dominance effects of the quantitative trait locus.
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