- Thursday, March 25, 2010
- High prevalence of hypokalemia after acute acetaminophen overdose: Impact of psychiatric illness
- Published at:Human and Experimental Toxicology, DOI: 10.1177/0960327110361759
Sa\'ed Zyoud1*, Rahmat Awang1, Syed Azhar Syed Sulaiman2, and Samah Al-Jabi3
1 WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), Penang, Malaysia
2 Clinical Pharmacy program, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Penang, Malaysia
3 College of pharmacy, An-Najah National University, Nablus, Palestine
* To whom correspondence should be addressed. E-mail: [email protected] .
Background: Hypokalemia is not an isolated disease but an associated finding in a number of different diseases. It is also a commonly neglected condition among patients with acute acetaminophen overdose. Objectives: This study intended to determine the prevalence of hypokalemia and its clinical correlates in acute psychiatric illness among hypokalemic and normokalemic patients after acetaminophen overdose. Methods: This is a retrospective cohort study of hospital admissions for acute acetaminophen overdose conducted over a period of 5 years from 1 January 2004 to 31 December 2008. Demographic data and different types of psychiatric illness were compared between hypokalemic and normokalemic patients. Hypokalemia was predefined by a serum concentration <3.5 mmol/L. Statistical Package for Social Sciences (SPSS) 15 was used for data analysis. Results: Two hundred and eighty patients out of 305 admissions were studied. Hypokalemia was found in 63.6% of patients with a higher prevalence in the presence of psychiatric illness (67.7%). Hypokalemic patients were significantly associated with the presence of major depression (p = .04), adjustment disorder (p < .001), anxiety (p = .01), and suicidal attempts (p = .04). Conclusion: Hypokalemia was common among patients with psychiatric illness and acute acetaminophen overdose.