An-Najah National University

Maher Abdel Razzak Abu-Eid Natsheh


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  • Saturday, January 27, 2001
  • Spectrophotometric Determination of Tiopronin in Pharmaceutical Preparations
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  • Two spectrophotometric methods are described for the determination of tiopronin in pharmaceuticals. They are based on the oxidation-reduction reaction between tiopronin and iron (III), then forming a complex between iron (II) and ferrozine or di-2-pyridyl ketone-2-thiophenoylhydrazone. The produced colored iron (II)-ferrozine complex [system I] absorbs at 562 nm, while the iron (II)-di-2-pyridyl ketone-2-thiophenoylhydrazone complex [system II] absorbs at 656 nm. The effect of different factors such as: pH, reagent concentration, time of reaction, temperature and the tolerance amount of the common excipients have been studied. Applying the optimum

    working conditions, tiopronin can be determined over the range 0.2-8.6 and 0.5-17.0 ppm and with molar absorptivities of 2.0x10

    4 and 1.0x104 l mol-1cm-1  for systems I and II, respectively. Both methods offer high selectivity, sensitivity and accuracy with a relative standard deviation (RSD) of less than 1.1% for five measurements. The proposed methods were applied successfully for the determination of tiopronin in

    Captimer tablets.

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Maher Abdel Razzak Abu-Eid Natsheh
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