- Thursday, January 1, 2009
- Antibacterial Activity of Common Varthemia, Varthemia iphionoides Ethanol Extract Alone and in Combination with Cefotaxime
- Published at:Advances in Biological Research 3 (5-6): 144-147, 2009
To assess the clinical utility of the crude ethanolic extract of the leaves of Varthemia iphionoides (Compositae), minimal inhibitory concentrations eJ\'v1Ies) were determined using agar dilution technique. Accordingly, The MICs of this plant extract ranged from 0.0313-1 mg/ml for three clinical Staphylacaccus aureus strains and ATCC strains of Bacillus subtilis and Staphylococcus epidermidis, whereas Escherichia coli studied in this report was fOlUld to exhibit higher 1v1Ie value (4 mg/ml). The effect of combinations of ethanolic extract of Varthemia iphionoides and cefotaxime was investigated by means of fractional inhibitory concentration (FIe) indices. Using the FIe indices, synergistic interactions were observed against B. subtilis (ATCC 6633) and S. aureus strains (FIC indices of 0.75-0.875); while combinations against E. cali and S. epidermidis (ATCC 25923) exhibited antagonistic interactions (FIC indices of 2.5 to 16.4). Synergy was confirmed at cefotaxime concentrations corresponding to 1/2 MIC and an ethanol extract concentrations corresponding to 1/41v1IC and lower.