An-Najah National University

Publications of Waleed M. Sweileh,

Research Interests: 1.Clinical Renal Pharmacology and Therapeutics 2.Evidence Based Pharmacotherapy 3.Pharmacoepidemiology

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  • Saturday, February 4, 2006
  • Drug Interactions and Risk of Bleeding among Patients with Atrial Fibrillation (AF) Discharged with Warfarin.
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    Drug Interactions and Risk of Bleeding among Patients with Atrial

    Fibrillation (AF) Discharged with Warfarin


    Waleed Sweileh, Nidal Jaradat, Moueen Elawee, Asaad Al-Shakhsheer,

    Ansam Sawalha, Rawa Al-Ramahi, & Abed Al-Naser Zaid.

    Faculty of Pharmacy, An-Najah University, Nablus, Palestine

    E-mail: [email protected]

    Received: (25/7/2005), Accepted: (5/9/2006)


    The objective of this study was to examine and evaluate the frequency of

    bleeding and serious drug interactions among patients with atrial fibrillation

    (AF) treated with oral anticoagulant [Warfarin]. A random sample of 59

    patients from Al-Watni government hospital in Nablus with a principal or

    secondary discharge diagnosis of AF was identified. All drug and clinical data

    were abstracted from the patient\'s files. We excluded patients who were less

    than 65 years of age, or left the hospital against medical advice, and those

    whose AF was transient or could not be confirmed. Of the original 59 AF

    patients, 19 were cliagnosed who were discharged on Warfarin. The mean age

    for these patients was 71.7 years. Among the patients discharged on Warfarin,

    94.7 % had one or more drug – drug interactions that could lead to increase risk

    of bleeding. Many patients discharged on Warfarin were having multiple

    interacting drugs. Patient counseling and follow-up monitoring are essential and

    should be carried out to minimize the risk of bleeding and other complications.

    Key Words:



    atrial fibrillation, warfarin, drug interactions, bleeding, stroke,



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Waleed M. Sweileh, Professor of Clinical Pharmacology & Pharmacy:
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