An-Najah Blogs :: Randa Y. Arafat An-Najah Blogs :: Randa Y. Arafat en-us Wed, 29 Jun 2022 21:51:35 IDT Wed, 29 Jun 2022 21:51:35 IDT Synthesis of a new series of heterocyclic scaffolds for medicinal purposes ArticlesA new series of substituted 8-fluro-4H-pyrimido[21-b] [13]benzothiazole-4-ones substituted 7-methyl-4H-isoxazolo[23-a]pyrimidin-4-ones and substituted 2-methyl-5678-tetrahydro-9H-isoxazolo[23-a]pyridopyrimidin-9-ones compounds IVII have been prepared via condensation of -keto esters with 2-aminopyridine derivatives in the presence of polyphosphoric acid The same technique has also been used to prepare diazepine compounds VIIIX by condensation of a -keto ester with 2-aminopyridine derivatives Details of synthetic procedures are shown The new compounds have been characterized by elemental analysis GCMS FT-IR and NMR spectrometry Antibacterial antifungal and anticancer cytotoxic activities for three of these compounds have been investigated and are presented European Journal of Medicinal Chemistry Volume 41 Issue 8 August 2006 Pages 1017-1024 http:dxdoiorg101016jejmech200603025