An-Najah Blogs :: Pharmacy http://blogs.najah.edu/author/mjmusmar An-Najah Blogs :: Pharmacy en-us Thu, 21 Sep 2017 15:27:29 IDT Thu, 21 Sep 2017 15:27:29 IDT webmaster@najah.edu webmaster@najah.edu Comparison of peak expiratory flow rates applying European and Iranian equations to Palestinian students http://blogs.najah.edu/staff/mjmusmar/article/Comparison-of-peak-expiratory-ow-rates-applying-European-and-Iranian-equations-to-Palestinian-students-Published Articles Comparison of peak expiratory ow rates applying European and Iranian equations to Palestinian students SGhazal-Musmar13 MMusmar 2 and WAMinawi 3 ABSTRACT Measurement of peak expiratory ow rate PEFRis required for effective asthma treatmentbut ethnic differences affect the application of prediction equations for lung functionPEFR was measured in a representative sample of 1000 students in NablusPalestinePredicted PEFR equations for Europeans and Iranians were applied to both males and females in age groups 21 and 21 yearsThere was a statistically signicant correlation between the predicted PEFR values in Palestinians and both equations in both males and females regardless of ageEquations developed on Iranians were more useful for Palestinians than the European equationsbut there is a need to develop our own nomograms مقارنة سرعات جريان الزفير الأقصى بتطبيق معادلات أوربية وإيرانية على طلاب فلسطينيـين سمر غزال مسمار، محمد جواد مسمار، وفاء ميناوي الخلاصـة : إن إجراء قياس سرعة جريان الزفير الأقصى ضروري من أجل المعالجة الفعَّالة للربو، إلا أن التفاوتات الإثنية تؤثر على تطبيق معادلات التنبؤ بوظائف الرئة وقد قاس الباحثون سرعة جريان الزفير الأقصى في عينة ممثلة تـتألف من ألف طالب من نابلس في فلسطين، وطبقوا معادلات التنبؤ بسرعة جريان الزفير الأقصى الأوروبية والإيرانية على كل من الذكور والإناث في مجموعتين عمريتين هما أقل من 21 عاما ً، و 21 ً عاما أو أكثر واتضح للباحثين وجود ترابط إحصائي ي ُعتد به بين قيم سرعة جريان الزفير الأقصى التنبؤية لد الفلسطينيـين في كلا المعادلتين في ٍ كل من الذكور والإناث، بغض النظر عن الأعمار كما لاحظوا أن المعادلات التي أعدت للإيرانيـين أكثر فائدة للفلسطينيـين من تلك التي أعدت للأوروبيـين، ولكن هناك حاجة لإعداد مخططات السواء الخاصة بالفلسطينيـين أنفسهم Comparaison du dbit expiratoire de pointe avec application dquations europennes et iraniennes aux tudiants palestiniensRSUM La mesure du dbit expiratoire de pointe DEPest ncessaire pour traiter efficacement lasthmemais des diffrences ethniques affectent lapplication des quations de prdiction de la fonction pulmonaireLe DEP a t mesur sur un chantillon reprsentatif de 1 000 tudiants de Nablus PalestineLes quations de prdiction du DEP pour les Europens et les Iraniens ont t appliques aussi bien aux filles quaux garons dans des groupes gs de moins de 21 ans et de 21 ans et plusUne corrlation statistiquement importante entre les valeurs du DEP prvues chez les Palestiniens et les quations aussi bien chez les hommes que chez les femmesindpendamment de lgea t observePour les Palestiniensles quations dveloppes pour les Iraniens taient plus utiles que les quations europennesmais il est ncessaire de dvelopper nos propres nomogrammes see the attachment Prevalence of Allergic Rhinitis and it’s Risk Factors Among An-Najah University Students - Nablus, Pakistanhttp://blogs.najah.edu/staff/mjmusmar/article/Prevalence-of-Allergic-Rhinitis-and-itrsquos-Risk-Factors-Among-An-Najah-University-Students---Nablus-PakistanPublished ArticlesBackground: Inhalant allergic conditions such as seasonal and perennial allergic rhinitis are becoming quite common The effect of allergy on an individuals quality of life and the extent to which it may restrict daily activities is often overlooked Controlling allergies can significantly decrease health care cost The purpose of this study is to estimate the prevalence of allergic rhinitis among young adults in Palestine represented by An- Najah University students Methods: The study sample consisted of around 1000 52 females 48 males randomly selected students from all colleges of the University Data were collected through structured interview including questionnaire filling All data were analysed using SPSS program applying Chi-square test with 95 level of significant P value = 005 Results: Allergic rhinitis prevalence rate was 31 and the percentage of patients who reported to have allergic rhinitis was 381; there was no statistically significant association between allergic rhinitis and gender smoking place of living and other housing conditions On the other hand the relationship between allergic rhinitis and weight loss deep sleeping chronic respiratory infections nasal polyps anxiety and sleep apnoea was a statistically significant relationship p value 005 The triggers that have a large effect on the health of the population sample for allergic rhinitis were respiratory infections tyre burning and war gases house dust strong odours auto exhaust smoke and weather changes 497 49 1 467 406 339 338 342 respectively Conclusion: Results show relatively lower allergic rhinitis prevalence in Palestine compared to some neighbouring countries but were consistent with studies done in Turkey The results confirmed the strong relationship of Allergic Rhinitis and respiratory infections and AsthmaHousing environment and women's health in a Palestinian refugee camphttp://blogs.najah.edu/staff/mjmusmar/article/Housing-environment-and-womens-health-in-a-Palestinian-refugee-campPublished ArticlesThis study was carried out during January and February 2002 in Al- Ein Refugee Camp in Nablus city in Palestine Interviews were held with 150 women of different age groups and different marital status The results show a positive relationship between womens physical and mental health and housing conditions There is a statistically significant relationship between the family size represented by the number of children in the household the number of children that sleep in one room and the number of children that sleep in one bed the house size and number of rooms and womens feeling of privacy mental health and well-being Most of the houses in the camp are unhealthy and overcrowded The family income is very low and there is a general poor health status of women in the camp Most of the women do not know the conditions of a healthy house The study shows the importance of housing reforms on the health of the family in general and womens health in particular mainly in refugee camps International Journal of Environmental Health Research Volume 15 Number 3 June 2005 pp 181-19111Effect of IUD (Intra uterine device) on reproductive tract Infection (RTI) in the northern west bank http://blogs.najah.edu/staff/mjmusmar/article/Effect-of-IUD-Intra-uterine-device-on-reproductive-tract-Infection-RTI-in-the-northern-west-bank-Published Articles Background: Intra uterine device IUD is one of the most popular methods of contraception among Palestinian women Reproductive Tract Infection RTI is one of the main problems associated with IUD use The objective of this study is to explore the relationship between RTI related symptoms IUD use Methods: We interviewed two hundred women 134 IUD users and 66 non-IUD users from Ministry of Health MOH family planning FP clinics in Northern West BankPalestine A questionnaire about RTI related symptoms was filled then cervical swab samples were collected cultured for aerobic bacteria A scoring system for vaginal discharge symptoms and overall RTI related symptoms was developed all data were analyzed using SPSS software Results: High number 87 of women in the study reported vaginitis or RTI symptoms There was a significant difference in alteration of vaginal discharge P=0003 and presence of RTI related symptoms P=0000 among IUD users in comparison to nonusers However there was no statistically significant relationship between alteration of vaginal discharge and type of isolated bacteria P=0266 nor was a relation between RTI related symptoms and IUD type P=0568 Conclusion: Vaginitis and RTI are common problems among women in Palestine with a high association between IUD use and these types of infection A protocol for diagnosis and treatment needs to be developed by MOH and other health organizations in Palestine Epidimiology of Aerobic Bacterial Infections among IUD (Intrauterine ‎Device) Users in the Northern West Bankhttp://blogs.najah.edu/staff/mjmusmar/article/Epidimiology-of-Aerobic-Bacterial-Infections-among-IUD-Intrauterine-lrmDevice-Users-in-the-Northern-West-BankPublished ArticlesIntra uterine device IUD is the most popular method of contraception among Palestinian women It is one of the very effective contraceptive methods with very small failure rate Infection has been the main problem that faces women using IUD all over the world The aim of this study is to explore the epidemiological pattern of aerobic bacterial infections among IUD users in Northern West Bank Palestine A study sample included two hundred women 134 IUD users and 66 non-IUD users from MOH Ministry of Health FP family planning clinics These women were randomly selected interviewed then cervical swabs were collected and cultured for aerobic bacteria all data were analyzed using SPSS software The study results showed overall significant higher rate of isolated bacteria among IUD users compared to non-users P value 005 with a significant relationship between infection and the type of IUD However there was no overall significance in relation to duration of use P value 005 More than 50 of the positive culture results were predominant bacteria and some 40 were potentially pathogenic ? Hemolytic streptococcus was the most frequent of the former and E Coli of the latter Overall the study results were consistent with the current literature An-Najah University Journal for Research - Natural Sciences A ISSN: 1727-2114 Volume 18 Issue 1 2004 Pages: 013-024Osmium(VIII)-Catalyzed Oxidation of Some Cyclic Amines by Potassium Hexacyanoferrate(III) in Alkaline Media: a Kinetics and Mechanistic Studyhttp://blogs.najah.edu/staff/mjmusmar/article/OsmiumVIII-Catalyzed-Oxidation-of-Some-Cyclic-Amines-by-Potassium-HexacyanoferrateIII-in-Alkaline-Media-a-Kinetics-and-Mechanistic-StudyPublished ArticlesReactions of morpholine piperidine and piperazine with OsVIII-catalyzed hexacyanoferrateIII in alkaline media to produce the corresponding lactam have been studied at constant temperature and ionic strength The reactions followed first-order kinetics with respect to [amine] and [OsVIII] but were independent of [FeCN6 3-] and [OH-] The effects of introduced electrolytes potassium hexacyanoferrateII relative permitivity and temperature have also been studied A mechanism accounting for these results has been proposed Chemistry of Heterocyclic Compounds Volume 39 Number 4 April 2003 http:wwwspringerlinkcomcontentj06688m34677p8w0Oxidation of some Alicyclic Aminesby Potassium Hexacyanoferrate (III) in Alkaline Medium : AKinetic and Mechanistic Studyhttp://blogs.najah.edu/staff/mjmusmar/article/Oxidation-of-some-Alicyclic-Aminesby-Potassium-Hexacyanoferrate-III-in-Alkaline-Medium--AKinetic-and-Mechanistic-Study-1Published ArticlesAbstract Oxidation of some alicyclic amines morpholine piperazine and piperidine by potassium hexacyanoferrateIII in basic medium has been investigated at 35C Stoichiometric results showed that four moles of hexacyanoferrateIII were consumed per mile of piperidine or morpholine whereas piperazine consumed eight moles of the oxidant to produce the corresponding lactams Kinetic studies indicated that piperidine and morpholine also followed different Kinetics from that of piperazine being first order in the amine concentration and independent of the concentrations of hexacyanoferrateIII and hydroxide ion while in the case of piperazine the reaction was first order in both oxidant and substrate concentrations and zero order with respect to the concentration of hydroxide ion The changes in reaction rate due to changing ionic strength of the medium as well as other factors has also been investigated The activation parameters of the oxidation process have been evaluated and a mechanism consistent with the observed Kinetics has been proposed Oxidation of some Alicyclic Amines by Potassium Hexacyanoferrate (III) in Alkaline Medium: A Kinetic and Mechanistic Studyhttp://blogs.najah.edu/staff/mjmusmar/article/Oxidation-of-some-Alicyclic-Amines-by-Potassium-Hexacyanoferrate-III-in-Alkaline-Medium-A-Kinetic-and-Mechanistic-StudyPublished ArticlesOxidation of some alicyclic amines morpholine piperazine and piperidine by potassium hexacyanoferrate??? in basic medium has been investigated at 35C Stoichiometric results showed that four moles of hexacyanoferrateIII were consumed per mole of piperidine or morpholine whereas piperazine consumed eight moles of the oxidant to produce the corresponding lactams Kinetic studies indicated that piperidine and morpholine also followed different kinetics from that of piperazine being first order in the amine concentration and independent of the concentrations of hexacyanoferrate??? and hydroxide ion while in the case of piperazine the reaction was first order in both oxidant and substrate concentrations and zero order with respect to the concentration of hydroxide ion The changes in reaction rate due to changing ionic strength of the medium as well as other factors has also been investigated The activation parameters of the oxidation process have been evaluated and a mechanism consistent with the observed kinetics has been proposed Keywords: Hexacyanoferrate??? morpholine piperazine piperidine oxidation lactam An-Najah University Journal for Research - Natural Sciences A ISSN: 1727-2114 Volume 15 2001 Pages: 029-039Adsorptive Stripping Voltammetric Determination of Albendazole at a Hanging Mercury Drop Electrodehttp://blogs.najah.edu/staff/mjmusmar/article/Adsorptive-Stripping-Voltammetric-Determination-of-Albendazole-at-a-Hanging-Mercury-Drop-ElectrodePublished ArticlesAlbendazole is determined by differential-pulse adsorptive cathodic stripping voltammetry at a hanging mercury drop electrode using the reduction peak of its copperII complex at -028V at an accumulation potential 00V vs AgAgCl electrode The optimum conditions of pH accumulation potential and accumulation time were studied The calibration graph for the determination of albendazole was linear in the range 30X10-8 - 9X10-7M with a relative standard deviation of 28 The detection limit was 10X10-8M after 180s accumulation at 00V The effect of common excipients and metal ions on the peak height of albendazole was studied The presence of Cu2 ions forms a stable complex with albendazole which is strongly adsorbed at the mercury electrode surface The method was applied to the determination of the drug in commercially available dosage forms Analytical Letters Volume 32 Issue 15 1999 pages 2965 - 2975The Synthesis of Novel Polycyclic Heterocyclic Ring Systems via Photocyclization. Three New Derivatives of Carbazole http://blogs.najah.edu/staff/mjmusmar/article/10-Ethyl-1-fluoro-lOH-1benzothieno3245lpyrido23-ccarbazole-10-ethyl-IOHJ1-benzothieno3245pyrido23-ccarbazole-and-12-ethyl-12H-naphtho1quot2quot45thieno-3245pyrido23-ccarbazole-were-prepared-Starting-with-the-corresponding-acid-chlorides-namely-4-flouro-3-chlorobenzobthiophene-2-carbonyl-chloride-3-chloronotbenzobthiophene-2-carbonyl-chloride-and-1-chloronaphtho21-bthiophene-2-carbonyl-chloride-each-carbonyl-chloride-was-then-allowed-to-react-with-3-amino-9-ethylcarbazole-The-carboxamides-thus-formed-were-converted-to-the-corresponding-lactams-by-irradiation-with-a-450-watt-Hanovia-medium-pressure-mercury-lamp-under-a-slow-stream-of-air-The-lactams-were-then-chlorinated-by-refluxing-in-phosphorus-oxychoride-The-carbazoles-were-then-stirred-with-10-PdC-under-a-hydrogen-atmosphere-to-effect-dechlorination-to-provide-the-N-ethy1-derivativesPublished Articles 10-Ethyl-1-fluoro-lOH-[1]benzothieno[32:45]pyrido[23-c]carbazole 10-ethyl-IOHJ1]benzothieno[32;45]pyrido[23-c]carbazole and 12-ethyl-12H-naphtho[12;45]thieno[32:45]pyrido[23-c]carbazole were prepared Starting with the corresponding acid chlorides namely 4-flouro-3-chlorobenzo[b]thiophene-2-carbonyl chloride 3-chlorobenzo[b]thiophene-2-carbonyl chloride and 1-chloronaphtho[21-b]thiophene-2-carbonyl chloride each carbonyl chloride was then allowed to react with 3-amino-9-ethylcarbazole The carboxamides thus formed were converted to the corresponding lactams by irradiation with a 450 watt Hanovia medium pressure mercury lamp under a slow stream of air The lactams were then chlorinated by refluxing in phosphorus oxychoride The carbazoles were then stirred with 10 PdC under a hydrogen atmosphere to effect dechlorination to provide the N-ethy1 derivatives The Synthesis of Novel Polycyclic Heterocyclic Ring Systems via Photocyclization. 14. 14-Methylbenzo[h]naphtho¬[1'2';4,5]thieno[2,3-c][ 1,6]naphthyridine http://blogs.najah.edu/staff/mjmusmar/article/The-Synthesis-of-Novel-Polycyclic-Heterocyclic-Ring-Systems-via-Photocyclization-14-14-Methylbenzohnaphthonot1245thieno23-c-16naphthyridine-Published Articles Benzo[h]naphtho[12:45]thieno[23-c][16]naphthyridine a novel polycyclic heterocyclic ring system has been synthesized as the 14-methyl derivative 8 in four steps from known intermediates The structure of 8 is supported by assignment of the proton and the protonated carbon atoms by 2D-nmr techniques COSY and a carbon-hydrogen one-bond coupling experiment Combined Application of Auto-Correlated (COSY) and Homonuclear J-Resolved Two-Dimensional NMR Spectra for the Assignment of Congested, Non-First Order Spectra of Polycyclic Aromatic Systems. Assignment of the 'H-NMR Spectrum of Benzo[2,3]phenanthro¬[4,5-bcd]thiophene and an Investigation of Long Range 'H-'H Spin-Coupling Constantshttp://blogs.najah.edu/staff/mjmusmar/article/Combined-Application-of-Auto-Correlated-COSY-and-Homonuclear-J-Resolved-Two-Dimensional-NMR-Spectra-for-the-Assignment-of-Congested-Non-First-Order-Spectra-of-Polycyclic-Aromatic-Systems-Assignment-of-the-H-NMR-Spectrum-of-Benzo23phenanthronot45-bcdthiophene-and-an-Investigation-of-Long-Range-H-H-Spin-Coupling-ConstantsPublished Articles Total assignment of the proton nmr spectrum of benzo[23]phenanthro[45-bcd]thiophene at 200 111z is reported Preliminary identification of the resonances comprising the individual spin systems was accomplished by the use of auto-correlated two-dimensional proton nmr spectroscopy COSY Individual assignments were made on the basis of spin-coupling information which was obtained from the titled two-dimensional J-resolved 2DJ proton nmr spectrum of the title compound Because of the greater resolving power of the latter experiment relative to conventional proton nmr spectroscopy a number of long range inter-ring spincouplings were observed The observation of these long range couplings was crucial to the final assignment of several of the resonances in the spectrum Resonances due to strong coupling in the 2DJ spectrum were also shown to be a useful means of correlating strongly coupled spins which provides an alternative to the COSY spectrum for this purpose The Synthesis of Novel Polycyclic Heterocyclic Ring Systems via Photocyclization.10 [1].Synthesis and Structure Determination of Naphtho[1',2':4,5]thieno[3,2-a]-4,7-phenanthrolinehttp://blogs.najah.edu/staff/mjmusmar/article/The-Synthesis-of-Novel-Polycyclic-Heterocyclic-Ring-Systems-via-Photocyclization-10-1-Synthesis-and-Structure-Determination-of-Naphtho1245thieno32-a-47-phenanthrolinePublished ArticlesAs a part of an extension of our synthetic work on photoinduced cyclization reactions[la-i] we now wish to report the synthesis of another hitherto unknown heterocvclic ring system namely naphtho[12:45]thieno[32-a]-47phenanthroline 6 The reaction of 1-chloronaphtho[21-b]thiophene-2carbonyl chloride 1 [3] with 6-aminoquinoline2provided1-chloro-N-quinolin-6-ylnaphtho[21-b]ihiophene-2carboxamide 3 in 85 yield Photocyclization of 3 afforded naphtho[l2:4a]thieno[32-a]-47-phenanthrolin87H-one 4 in 29 Yield Lactam 4 was chlorinated in refluxing phosphorus oxvchloride to give 8-chloronaphtho[l2:45]thieno[32-a]-47-phenanthroline 5 in 40 yield Catalytic dechlorination of compound 5 was accomplished with 10 PdC in a solution of potassium hydroxide methanol and benzene under a hydrogen atmosphere to yield naphtho[12:45]thieno[32-a]-47-phPnanthroline 6 in 63 yield The Synthesis of Substituted [1]Benzothieno[2,3-c]quinolines and their N-methyl Quaternary Saltshttp://blogs.najah.edu/staff/mjmusmar/article/The-Synthesis-of-Substituted-1Benzothieno23-cquinolines-and-their-N-methyl-Quaternary-SaltsPublished Articles Four substituted [1]benzothietto[23-c]quinolines 14a-14d were prepared by photocyclization of the appropriate carboxamides 8a-8d to the corresponding [1]benzothieno[23-c]quinolin-65H-ones 12a-12d followed by chlorination to 6-c:hloro[1]benzothieno[23-c]quittolines 13a-13d and dechlorination resulting in the title compounds Treatment of 14a-14d with iodomethane furnished the corresponding N-methyl quaternary salts 5a-5d Complete Assignment of the 1H and 13C NMR Spectra of 11,12-Dimeth-oxy[1]benzothieno[3,2-a]-4,7-phenanthroline and its 8-Chloro Analogue: Concerted Use of Two-Dimensional NMR Techniques [1] http://blogs.najah.edu/staff/mjmusmar/article/Complete-Assignment-of-the-1H-and-13C-NMR-Spectra-of-1112-Dimeth-oxy1benzothieno32-a-47-phenanthroline-and-its-8-Chloro-Analogue-Concerted-Use-of-Two-Dimensional-NMR-Techniques-1-Published Articles The 1H and 13C nmr spectra of 1112-dimethoxy[1]benzothieno[32-a]47-phenanthroline and its 8-chloro precursor were totally assigned using a combination of two-dimensional nmr techniques After correlation of the majority of the proton signals by a COSY spectrum and one-bond heteronuclear correlation the full assignment of the 1H and 13C nmr spectra of the novel heterocyclic compounds required the application of long-range CH coupling information particularly for quaternary carbon resonance assignments and the orientations of individual spin systems relative to one another Key long-range heteronuclear couplings in both compounds served to confirm the one-bond heteronuclear correlations Unequivocal interpretation of the spectral data leads to the complete assignments of the reasonances The Synthesis of Novel Polycyclic Heterocyclic Ring Systems via Photocyclization. 3 [1]. 12-Methylbenzo[h][1]benzothieno[2,3-c][1,6]naphthyridine http://blogs.najah.edu/staff/mjmusmar/article/The-Synthesis-of-Novel-Polycyclic-Heterocyclic-Ring-Systems-via-Photocyclization-3-1-12-Methylbenzoh1benzothieno23-c16naphthyridine-Published ArticlesThe synthesis of the 12-methyl derivative of a novel hcterocyclic ring system namely benzo[h][l]benzothieno[23-c][16]naphthyridine 8 was prepared by photocyclization of 3-chloro-N-2-methyl-4-quinolylbenzo[h]thiophene-2-carboxamide 5 to 12-methylbenzo[h][1]benzothieno[23-c][16]nalththyridin-65N}one6Chlorination of 6 afforded 6-chloro-12-methylbenzo[h][1]benzothieno[23-c][16]naphthyridine 7 which upon dechlorination provided the novel title compound 8Chemistry of the Phenoxathiins and Isosterically Related Heterocycles. XXXVII+. The Synthesis and Molecular Structure of Benzo[2,3]naphtho[5,6,7-ij][1,4]dithiepin and its 1-Oxide http://blogs.najah.edu/staff/mjmusmar/article/Chemistry-of-the-Phenoxathiins-and-Isosterically-Related-Heterocycles-XXXVII-The-Synthesis-and-Molecular-Structure-of-Benzo23naphtho567-ij14dithiepin-and-its-1-Oxide-Published Articles Benzo[23]naphtho[567-ij[l4]dithiepin was prepared by the condensation of the disodium salt of 12-dimercaptobenzene with 1-chloro-8-nitronaphthalene The structure was established by nmr and mass spectroscopy A small quantity of benzo[23]naphtho[567-ij][1-4]dithiepin 1-oxide was also isolated The structure was initially established by mass spectrometry The proton spectrum was totally assigned using a combination of proton zero quantum coherence ZQCOSY and proton-carbon heteronuclear chemical shift correlation HC-COSY techniques which also allowed the unequivocal assignment of the protonated carbon resonances An X-ray crystal structure of the 1-oxide irrefutably confirmed the structure The crystal was triclinic and the space group was PI and the data refined to a final R = 00353 The molecule was shown to be folded about the axis passing through the two sulfur atoms with a dihedral angle of 10900 Benzo[b]phenanthro[4,3-d]thiophene: Spectral Assignment by Two-Dimensional NMR Methods and Tertiary Structure Determinationhttp://blogs.najah.edu/staff/mjmusmar/article/Benzobphenanthro43-dthiophene-Spectral-Assignment-by-Two-Dimensional-NMR-Methods-and-Tertiary-Structure-DeterminationPublished Articles Two-dimensional heteronuclear chemical shift correlation heteronuclear relayed coherence transfer and autocorrelated 13C--13C double quantum coherence have been used to assign the proton and 13C NMR spectra of benzo[b]phenanthro[43-d]thiophene The highly complementary nature of the heteronuclear relay and carbon-carbon double quantum spectra conveniently provides the means of avoiding breaks in the carbon-carbon connectivity network assembled by the latter which may arise when strongly AB rather than AX carbon-carbon pairings are encountered Nuclear Overhauser difference spectra have shown the title compound to possess a tertiary helical structure similar to that of phenanthro[34-b]thiophene; the average separation between the H-1 and H-13 atoms of the title compound was found to be 206 004 Two Dimensional NMR Studies of Marine Natural Products. III.1 Reassignment of the 13C-NMR Spectrum of Brianthein-X Using Heteronuclear Relayed Coherence Transferhttp://blogs.najah.edu/staff/mjmusmar/article/Two-Dimensional-NMR-Studies-of-Marine-Natural-Products-III1-Reassignment-of-the-13C-NMR-Spectrum-of-Brianthein-X-Using-Heteronuclear-Relayed-Coherence-TransferPublished ArticlesDuring an investigation of the diterpene constituents of Briareum asbestinum we isolated the previously reported brianthein-X Through the use of two-dimensional heteronuclear chemical shift correlation and relayed coherence transfer four of the previously reported 13C-resonance assignments are revised Spectroscopy Letters Volume 19 Issue 5 June 1986 pages 545 - 557Two Polymorphs of 4,5-Dichloro-6(1H)-pyridazinonehttp://blogs.najah.edu/staff/mjmusmar/article/Two-Polymorphs-of-45-Dichloro-61H-pyridazinonePublished Articles C4H2CI2N:O Mr= 16499; form 1: monoclinic P21c a = 51967 12 b = 9046 2c = 12901 3 = 100090 15 V = 5971 2 3 Z=4Dx= 184g cm-3Mo Ka =071069 = 993 cm -1 F000 = 328 T= 163 K R = 0028 for 1552 reflections; form II: monoclinic P21 c a = 53384 7 b = 13827 2 c = 79107 12 =94397 14 V = 58220 14 A3 Z = 4 Dx = 188 g cm-3 Mo Ka = 071069 = 1018 cm -1 F000 = 328 T= 163 K R = 0025 for 1597 reflections The compound in each form exists in the oxo form and crystallizes as hydrogen-bonded dimers Infinite layers of dimers result from C-H O- and C HCI-type H bonds for forms I and II respectively [HO 225 2 CO 3076 2; H---CI 274 2 C---CI 3534 1 ] There are only minor differences in the bond distances and angles of the two formsAssignment of the 13C-NMR Spectrum of Phenanthro[4,3-a]dibenzo-thiophene Through the Utilization of Two-Dimensional Relayed Coherence Transfer and Double Quantum Coherence Spectroscopyhttp://blogs.najah.edu/staff/mjmusmar/article/Assignment-of-the-13C-NMR-Spectrum-of-Phenanthro43-adibenzo-thiophene-Through-the-Utilization-of-Two-Dimensional-Relayed-Coherence-Transfer-and-Double-Quantum-Coherence-SpectroscopyPublished Articles Total assignment of the 13C-nmr spectrum of the helical molecule phenanthro[43-a]dibenzothiophene at 125762 MHz is reported Assignments were made by the combined application of 13C-13C autocorrelated double quantum coherence and heteronuclear relayed coherence transfer RELAY experiments 1-Methylphenanthro[3,4-b]thiophene: Determination of the Tertiary Structure in Solution and in the Crystalline State by NMR Spectroscopy and X-Ray Diffractionhttp://blogs.najah.edu/staff/mjmusmar/article/1-Methylphenanthro34-bthiophene-Determination-of-the-Tertiary-Structure-in-Solution-and-in-the-Crystalline-State-by-NMR-Spectroscopy-and-X-Ray-DiffractionPublished Articles I-Methylphenanthro[34-blthiophene was prepared by the photocyclization of 1-4-methyl-2-thicnyl-2{2naphthylethene The 1H and 13C-nmr spectra were assigned using two-dimensional 1H13C heteronuclear chemical shift correlation and relayed coherence transfer RELAY experiments From nuclear Overhauser difference spectra the H11-C1 methyl-H intramolecular distance was determined to be 210 The molecule crystallized front chloroform in the monoclinic system space group P21c A total of 3536 unique reflections were measured and the structure was solved by direct methods and refined to a final R = 0049 The molecule is helical with both chiral forms observed in the crystal The H11-C1 methyl-H distance in the crystal was 2123 in excellent agreement with the distance measured in solution by NOE techniques Two-Dimensional Relayed Coherence Transfer Experiments as a Means of Subgrouping Protonated Carbon Resonances of Complex Polynuclear Heteroaromatics on the Basis of Vicinal Proton-Proton Connectivitieshttp://blogs.najah.edu/staff/mjmusmar/article/Two-Dimensional-Relayed-Coherence-Transfer-Experiments-as-a-Means-of-Subgrouping-Protonated-Carbon-Resonances-of-Complex-Polynuclear-Heteroaromatics-on-the-Basis-of-Vicinal-Proton-Proton-ConnectivitiesPublished ArticlesAbstract Application of autocorrelated homonuclear COSY and proton-carbon chemical shift correlation two-dimensional nmr experiments to the problem of assigning the H- and C-nmr spectra of phenanthro[43-aldibenzothiophene fails despite their considerable utility in the assignment of the spectra of the smaller phenanthro[b]thiophenes The failure of these techniques in the case of phenanthro[43-aldibenzothiophene is predominantly due to the inability of the COSY spectrum to provide the means of subgrouping the proton resonances into their component spin subsystems Two-dimensional relayed coherence transfer nmr experiments which first established coherence between vicinally coupled protons which is then transferred to the carbon spins which are ultimately observed circumvent these problems The application of two-dimensional relayed coherence transfer to phenanthro[43-a]dibenzothiophene is described the technique leading to the subgrouping of all five of the proton spin subsystems and thus providing a means of beginning the total assignment The Synthesis and Properties of Polycyclic Aromatic Thiophenes and Related Heterocycles Occurring in Coal-derived Products http://blogs.najah.edu/staff/mjmusmar/article/The-Synthesis-and-Properties-of-Polycyclic-Aromatic-Thiophenes-and-Related-Heterocycles-Occurring-in-Coal-derived-Products-Published Articles As the supplies of petroleum diminish it will become necessary to search for other sources of liquid fuels Because of the relatively large coal reserves available worldwide this appears to be the logical source of additional quantities of liquid fuels Recently much attention has been focussed on coal liquification and as recently as September 1982 the Division of Fuel Chemistry of the American Chemical Society sponsored a Symposium on Coal Liquification [7] In contrast with petroleum the components of coal coal liquids and other coal-derived products are primarily aromatic in nature and as a result present considerably greater health hazards when produced and handled on a large scale There have been many different structures proposed for coal Autocorrelated 13C-13C Double Quantum Coherence Two-Dimensional NMR Spectroscopy: Utilization of a Modified Version of the Technique as an Adjunct in the Total Assignment of the 1H- and 13C-NMR Spectra of the Mutagen Phenanthro[3,4-b]thiophenehttp://blogs.najah.edu/staff/mjmusmar/article/Autocorrelated-13C-13C-Double-Quantum-Coherence-Two-Dimensional-NMR-Spectroscopy-Utilization-of-a-Modified-Version-of-the-Technique-as-an-Adjunct-in-the-Total-Assignment-of-the-1H--and-13C-NMR-Spectra-of-the-Mutagen-Phenanthro34-bthiophenePublished Articles Development of successively higher field nmr spectrometers has facilitated the study of increasingly more complex molecules although smaller molecules such as phenanthro[34-blthiophene still offer very substantial assignment problems because of the highly congested nature of their 1H- and 13C-nmr spectra Assignments of such spectra if they are to be unequivocal frequently require the utilization of two-dimensional nmr spectroscopic techniques Total assignments of the 1H- and 13C-nrnr spectra of phenanthro[34-b]thiophene are reported Assignments were based on a conventional high resolution 500 MHz 1H-nmr spectrum autocorrelated two-dimensional 1H-nmr spectra COSY two-dimensional 1H-13C chemical shift correlation spectra and a modified version of autocorrelated 13C-13C double quantum coherence two-dimensional nmr spectroscopy From NOE measurements a separation of 199 between H1 and HI 1 was computed suggesting that phenanthro[34-b]thiophene has a pronounced helical conformation in solution Combined Application of Auto-Correlated (COSY) and Homonuclear J-Resolved Two-Dimensional NMR Spectra for the Assignment of Congested, Non-First Order Spectra of Polycyclic Aromatic Systems. Assignment of the 1H-NMR Spectrum of Benzo[2,3]phenanthro&not[4,5-bcd]thiophene and an Investigation of Long Range 1H-1H Spin-Coupling Constantshttp://blogs.najah.edu/staff/mjmusmar/article/Combined-Application-of-Auto-Correlated-COSY-and-Homonuclear-J-Resolved-Two-Dimensional-NMR-Spectra-for-the-Assignment-of-Congested-Non-First-Order-Spectra-of-Polycyclic-Aromatic-Systems-Assignment-of-the-1H-NMR-Spectrum-of-Benzo23phenanthronotPublished Articles Total assignment of the proton nmr spectrum of benzo[23]phenanthro[45-bcd]thiophene at 200-MHz is reported Preliminary identification of the resonances comprising the individual spin systems was accomplished by the use of auto-correlated two-dimensional proton nmr spectroscopy COSY Individual assignments were made on the basis of spin-coupling information which was obtained from the titled two-dimensional J-resolved 2DJ proton nmr spectrum of the title compound Because of the greater resolving power of the latter experiment relative to conventional proton nmr spectroscopy a number of long range inter-ring spectroscopy were observed The observation of these long range couplings was crucial to the final assignment of several of the resonances in the spectrum Resonances due to strong coupling in the 2DJ spectrum were also shown to be a useful means of correlating strongly coupled spins which provides an alternative to the COSY spectrum for this purpose Utilization of a Modified Version of the Technique as an Adjunct in the Total Assignment of the 'H- and "C-NMR Spectra of the Mutagen Phenanthro[3,4-b]thiophenehttp://blogs.najah.edu/staff/mjmusmar/article/Utilization-of-a-Modified-Version-of-the-Technique-as-an-Adjunct-in-the-Total-Assignment-of-the-H--and-quotC-NMR-Spectra-of-the-Mutagen-Phenanthro34-bthiophenePublished Articles Development of successively higher field nmr spectrometers has facilitated the study of increasingly more complex molecules although smaller molecules such as phenanthro[34-b]thiophene still offer very substantial assignment problems because of the highly congested nature of t1leir H- and C-nmr spectra Assignments of such spectra if they are to be unequivocal frequently require the utilization of two-dimensional nmr spectroscopic techniques Total assignments of the H- and C-nmr spectra of phenanthro[34-b]thiophene are reported Assignments were based on a conventional high resolution 500 MHz H-nmr spectrum autocorrelated two-dimensional H-nmr spectra COSY two-dimensional H-C chemical shift correlation spectra and a modified version of autocorrelated C-C double quantum coherence two-dimensional nmr spectroscopy From NOE measurements a separation of 199 A between H1 and HII was computed suggesting that phenanthro[34-b]thiophene has a pronounced helical conformation in solution Assignment of the High-Field Resonances of a Gorgosterol Derivative through the Use of Autocorrelated Two-Dimensional 1H NMR Spectroscopyhttp://blogs.najah.edu/staff/mjmusmar/article/Assignment-of-the-High-Field-Resonances-of-a-Gorgosterol-Derivative-through-the-Use-of-Autocorrelated-Two-Dimensional-1H-NMR-SpectroscopyPublished Articles Since the initial report describing the novel cyclopropane-containing side chain of gorgosterol several additional steroids containing this interesting side chain have been reported23 The 1H NMR spectra of all of these compounds exhibited signals for four high-field protons although only three such protons would be expected in the trisubstituted cyclopropane moiety In the specific case of gorgosterol the protons at b -013 and 044 were assigned as the cyclopropane methylene H30 protons One of the proton signals contained in the unresolved two-proton multiplet observed at S 006-037 was further assigned as the remaining cyclopropane resonance H22 on the basis of homonuclear decoupling experiments The identity of the remaining proton signal contained in this multiplet has however never been accounted for although it was suggested that that signal must be due to an unusually shielded proton not directly attached to the cyclopropane ring We have performed an NMR study of a secogorgosterol derivative 5a6cr-epoxy-311-dihydroxy-911-seco5a-gorgostan-9-one 311-diacetate 1 which also exhibitssee attached file