An-Najah Blogs :: An-Najah Blogs :: en-us Sat, 23 Sep 2017 06:57:59 IDT Sat, 23 Sep 2017 06:57:59 IDT Chewable tablets: Is this dosage form well evaluated by Palestinian health professionals? ArticlesAbstract: Objective: To evaluate the scientific knowledge assessment and attitudes of the three columns of health professionals in Palestine re the advantages of chewable tablets in comparison with other related dosage forms Methods: Data was gathered from a questionnaire that was handed out to community pharmacists Physicians Pharmaceutical industry decision makers were enrolled in this study Data was analyzed using spss statistical software program version 110 Results: Both pharmacists and doctors had very close opinions with regard to the superiority of chewable tablets over the corresponding liquid dosage forms especially when issues of palatability stability dose precision ease of administration portability and safety are mentioned Pharmacists and physicians were uncertain about the higher effectiveness of chewable tablets in comparison with other related dosage forms syrups and suspensions which contain the same active ingredients All industrial decision makers thought that the number of chewable tablet formulations present in Palestine is relatively low One third of them believed that this dosage form is not fully evaluated nor accepted by pharmacists and doctors About half of them thought that the lack of technology or specialized personnel is behind the reason for the poor development of this dosage form Conclusion: The importance of chewable tablets is not completely understood and appreciated by the Palestinian health personnel Pharmaceutical should pay more attention to the development and production of chewable tablets due to the valuable advantages of this dosage form Clear and complete information about this dosage form must be provided to pharmacists and physicians by medical rep of the pharmaceutical industryeffects of particle size and adding sequence of fine lactose on the deposition of salbutamol sulphate from a dry powder formulation. ArticlesTernary mixtures composed of coarse lactose CL 908 microm salbutamol sulphate SS 58 microm and either micronised lactose ML 5 microm or intermediate sized lactose IML 159 microm in a ratio of 665:1:1 ww were prepared using different mixing sequences of the various components In addition a binary mixture composed of CL and SS 675:1 ww was also prepared as the control The in vitro deposition of SS was measured using a twin stage impinger after aerosolisation at 60 and 90 l min-1 via a Rotahaler The aerodynamic particle size distribution of both the aerosolised SS and lactose was further analysed using an Andersen cascade impactor at 60 l min-1 All ternary mixtures produced a significantly higher analysis of variance P001 fine particle fraction FPF and fine particle dose FPD of SS than the control after aerosolisation at either 60 or 90 l min-1 Formulations containing the ML produced significantly P005 higher FPF and FPD of SS than those containing the IML at both aerosolisation flow rates Different mixing sequences were also shown to result in different deposition profiles of both SS and lactose after aerosolisation of the ternary mixtures containing ML at 60 l min-1 The formulation prepared by first blending ML with CL before mixing with SS produced a higher FPF and FPD of SS but a lower FPF of lactose than the same formulation in terms of composition but prepared using different mixing orders of the three components In contrast the formulations containing IML produced a similar deposition profile to SS regardless of the mixing sequences and so did the formulations containing ML aerosolised at 90 l min-1 These results suggest that the effect of mixing sequences on drug deposition may become more prominent at lower aerosolisation flow rates and by reducing the size of any added fine lactose